Cite Exposome Agent

If you use Exposome Agent in a manuscript, report, or slide deck, please cite the methodology paper, the web app, and any underlying data source you relied on.

Primary citation

Methodology paper — the exposome and EP-WAS framework underlying this app.

PLAIN

Patel, C. J., Ioannidis, J. P. A. & Manrai, A. K. An atlas of exposome–phenome associations in health and disease risk. Nature Medicine, 1–10 (2026). doi:10.1038/s41591-026-04266-0

BIBTEX

@article{patel_exposomeql_nm,
  author    = {Patel, C. J., Ioannidis, J. P. A. & Manrai, A. K.},
  title     = {An atlas of exposome–phenome associations in health and disease risk},
  journal   = {Nature Medicine},
  year      = {2026},
  pages     = {1–10},
  doi       = {10.1038/s41591-026-04266-0},
  url       = {https://doi.org/10.1038/s41591-026-04266-0}
}

https://doi.org/10.1038/s41591-026-04266-0

Methodology reference for the exposome and EP-WAS framework underlying Exposome Agent and Exposome Agent.

Web app

The Exposome Agent web interface (this app).

PLAIN

Patel Lab, Harvard Medical School. Exposome Agent (2026). https://github.com/chiragjp/exposomeqlweb

BIBTEX

@software{exposomeql_web,
  author = {Patel Lab, Harvard Medical School},
  title  = {Exposome Agent},
  year   = {2026},
  url    = {https://github.com/chiragjp/exposomeqlweb}
}

https://github.com/chiragjp/exposomeqlweb

TODO: update URL once the repository is public.

Data sources

Cite the specific dataset(s) you queried during the analysis.

NHANES — National Health and Nutrition Examination SurveyU.S. Centers for Disease Control and Prevention · National Center for Health Statistics

PLAIN

Centers for Disease Control and Prevention (CDC). National Center for Health Statistics. National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services.

https://www.cdc.gov/nchs/nhanes/

EP-WAS — Exposure-Phenotype-Wide Association CatalogPatel Lab, Harvard Medical School

PLAIN

EP-WAS: 66.8M exposure-phenotype associations pre-computed from NHANES 1999–2018 with multi-cycle pooling and Bonferroni / BH-FDR correction. See Patel et al., Nature Medicine (citation above).

https://github.com/chiragjp

HHEAR — Human Health Exposure Analysis ResourceNIH / NIEHS

PLAIN

National Institute of Environmental Health Sciences (NIEHS). Human Health Exposure Analysis Resource (HHEAR). Targeted biomonitoring cohort datasets. https://hhearprogram.org/

https://hhearprogram.org/

CTD — Comparative Toxicogenomics DatabaseThe Mount Desert Island Biological Laboratory

PLAIN

Davis AP, Wiegers TC, Sciaky D, Barkalow F, Strong M, Wyatt B, Wiegers J, McMorran R, Abrar S, Mattingly CJ. Comparative Toxicogenomics Database (CTD): a computational resource for integrated hypothesis generation and testing. Nucleic Acids Research.

https://ctdbase.org/

Curated nutrient RCT meta-analysesPatel Lab

PLAIN

Hand-curated set of 64 meta-analyses covering 17 nutrients and 75 outcome mappings, linked to NHANES phenotype variables. See the ExposomeQL MCP server's data/nutrient_rct_evidence.csv for provenance per row.

License

The ExposomeQL MCP server and the Exposome Agent web interface are released under the GNU Affero General Public License v3.0 (AGPL-3.0). NHANES and HHEAR data are subject to their respective terms of use; cite the originating agency as above.